-Continuing the Manhattan Project, researchers inject plutonium into three patients at the University of Chicago's Billings Hospital (Sharav).
-The U.S. State Department, Army intelligence and the CIA begin Operation Paperclip, offering Nazi scientists immunity and secret identities in exchange for work on top-secret government projects on aerodynamics and chemical warfare medicine in the United States ("Project Paperclip").
-Researchers infect 800 prisoners in Atlanta with malaria to study the disease (Sharav).
-(1945 - 1955) In Newburgh, N.Y., researchers linked to the Manhattan Project begin the most extensive American study ever done on the health effects of fluoridating public drinking water (Griffiths and Bryson).
-(1963 - 1966) New York University researcher Saul Krugman promises parents with mentally disabled children definite enrollment into the Willowbrook State School in Staten Island, N.Y., a resident mental institution for mentally retarded children, in exchange for their signatures on a consent form for procedures presented as "vaccinations." In reality, the procedures involve deliberately infecting children with viral hepatitis by feeding them an extract made from the feces of infected patients, so that Krugman can study the course of viral hepatitis as well the effectiveness of a hepatitis vaccine (Hammer Breslow).
-(1962) Researchers at the Laurel Children's Center in Maryland test experimental acne antibiotics on children and continue their tests even after half of the young test subjects develop severe liver damage because of the experimental medication (Goliszek). The U.S. Army's Deseret Test Center begins Project 112. This includes SHAD (Shipboard Hazard and Defense), which exposes U.S. Navy and Army personnel to live toxins and chemical poisons in order to determine naval ships' vulnerability to chemical and biological weapons. Military personnel are not test subjects; conducting the tests exposes them. Many of these participants complain of negative health effects at the time and, decades later, suffer from severe medical problems as a result of their exposure (Goliszek, Veterans Health Administration).
-The FDA begins requiring that a new pharmaceutical undergo three human clinical trials before it will approve it. From 1962 to 1980, pharmaceutical companies satisfy this requirement by running Phase I trials, which determine a drug's toxicity, on prison inmates, giving them small amounts of cash for compensation (Sharav).
-(1963) Chester M. Southam, who injected Ohio State Prison inmates with live cancer cells in 1952, performs the same procedure on 22 senile, African-American female patients at the Brooklyn Jewish Chronic Disease Hospital in order to watch their immunological response. Southam tells the patients that they are receiving "some cells," but leaves out the fact that they are cancer cells. He claims he doesn't obtain informed consent from the patients because he does not want to frighten them by telling them what he is doing, but he nevertheless temporarily loses his medical license because of it. Ironically, he eventually becomes president of the American Cancer Society (Greger, Merritte, et al.).
-Researchers at the University of Washington directly irradiate the testes of 232 prison inmates in order to determine radiation's effects on testicular function. When these inmates later leave prison and have children, at least four have babies born with birth defects. The exact number is unknown because researchers never follow up on the men to see the long-term effects of their experiment (Goliszek).
-In a National Institutes of Health-sponsored (NIH) study, a researcher transplants a chimpanzee's kidney into a human. The experiment fails (Sharav).
-In a study published in Pediatrics, researchers at the University of California's Department of Pediatrics use 113 newborns ranging in age from one hour to three days old in a series of experiments used to study changes in blood pressure and blood flow. In one study, doctors insert a catheter through the newborns' umbilical arteries and into their aortas and then immerse the newborns' feet in ice water while recording aortic pressure. In another experiment, doctors strap 50 newborns to a circumcision board, tilt the table so that all the blood rushes to their heads and then measure their blood pressure (Goliszek).
-(1964 - 1968) The U.S. Army pays $386,486 (the largest sum ever paid for human experimentation) to University of Pennsylvania Professors Albert Kligman and Herbert W. Copelan to run medical experiments on 320 inmates of Holmesburg Prison to determine the effectiveness of seven mind-altering drugs. The researchers' objective is to determine the minimum effective dose of each drug needed to disable 50 percent of any given population (MED-50). Though Professors Kligman and Copelan claim that they are unaware of any long-term effects the mind-altering agents might have on prisoners, documents revealed later would prove otherwise (Kaye).
-(1965) The Department of Defense uses human test subjects wearing rubber clothing and M9A1 masks to conduct 35 trials near Fort Greely, Ala., as part of the Elk Hunt tests, which are designed to measure the amount of VX nerve agent put on the clothing of people moving through VX-contaminated areas or touching contaminated vehicles, and the amount of VX vapor rising from these areas. After the tests, the subjects are decontaminated using wet steam and high-pressure cold water (Goliszek).
